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简体中文Technological Evolution
Courage and wisdom，continuous innovation
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tFNA
1st
Stem Cell Enhancers
Novel Nucleic Acid Nanomaterials with Regulatory Abilities
Overview：The first generation of tetrahedral framework nucleic acids, also known as stem cell enhancers, demonstrates significant effects through positive regulation of cellular biological behaviors. These effects are evident in areas such as tissue regeneration, fibrosis resistance, organ protection, and neural injury repair.
Key Applications：
Tissue Regeneration: Accelerates mucosal healing, promotes skin repair and regeneration, and supports cartilage repair and regeneration.
Neural System Repair:Treats Alzheimer’s disease, Parkinson’s disease, retinal ganglion cell regeneration, and spinal cord injuries.
Fibrosis and Organ Protection: Anti-pulmonary fibrosis, treatment of acute kidney injury, and management of type II diabetes complications.
Cellular Biological Effects: Regulates cell proliferation, migration, differentiation, and methylation levels, and promotes the differentiation of neural stem cells. -
tFNA
2nd
Drug and Gene Delivery Systems
Surface Modification of DNA, RNA, and PNA for Carrying Small Molecule Drugs
Overview：The second generation of tetrahedral framework nucleic acids leverages their excellent membrane penetration and transport capabilities to serve as carriers for genes and drugs in the treatment of various diseases.
Key Applications：
Gene Therapy: Carries DNA aptamers, antimicrobial genes, endonucleases, MicroRNA, etc., for treating conditions such as glaucoma, bone regeneration, and macular degeneration.
Drug Delivery: Delivers small molecule drugs like paclitaxel, temozolomide, and curcumin for treating cancer, gout, and type 2 diabetes.
Surface Modification: Alters metabolic pathways through surface modifications to enhance therapeutic efficacy and targeting.
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tFNA
3rd
Drug and Gene Delivery Systems
Innovative Design and Functional Expansion
Overview： The third generation of technology enhances the tetrahedral framework nucleic acids by altering their core structure to introduce new structural characteristics and functions. This includes applications such as nano-robots for precise protein removal and optimized drug-carrying capabilities of tetrahedra of different sizes.
Key Applications：
Carrying PNA Sequences: Inhibits bacterial growth.
Efficient Detection Systems: Uses tetrahedral frameworks for highly efficient DNA or RNA detection, significantly improving detection efficiency and sensitivity.
Solar Bird (BiRDS) Transdermal Delivery System: Inspired by the Sun Bird from the Sanxingdui site in Sichuan, this system integrates microRNA into the internal structure of the tetrahedron for enhanced transdermal delivery.
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tFNA
4th
Whole Genome Transcription System
Exploring the Frontier of Cognition
Overview： The fourth generation of technology is based on the DNA tetrahedral framework, utilizing the diversity of nucleic acid sequences to integrate genetic information into the nucleic acid framework, creating a high-information-density gene delivery system. This technology achieves more precise and efficient gene delivery with significant stability and controllability.
Key Applications:
Innovative Technology: This breakthrough technology surpasses the limitations of traditional viral and lipid-based systems, establishing a novel eukaryotic gene delivery system. By leveraging the DNA tetrahedral structure and nucleic acid diversity, this method addresses the issues of immune response and cytotoxicity found in traditional approaches, providing a safer and more efficient gene delivery route. It holds leading and revolutionary significance for gene therapy, drug development, and biomedical research.
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© 2024-2024 Yun Hai Biotech All rights reserved. Sichuan ICP No. 2024058099
Assisting the industrialization of framework nucleic acids，exploring new directions in life sciences
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Assistingthe industrialization of framework nucleic acids，exploring new directions in life sciences
© 2024-2024 Yun Hai Biotech All rights reserved. Sichuan ICP No. 2024058099 Human Resources：HR@yunhaibio.com
Business Development：BD@yunhaibio.com
Business Public Relations：PR@yunhaibio.com