2024 Research Achievements Summary of Professor Yunfeng Lin’s Team at Yunhai Bio

Songhang Li, Taoran Tian, Tao Zhang, Yunfeng Lin* and Xiaoxiao Cai*. A bioswitchable delivery system for microRNA therapeutics based on a tetrahedral DNA nanostructure. NatureProtocols.2024,https://doi.org/10.1038/s41596-024-01050-7 基于四面体DNA纳米结构的可生物切换microRNA治疗递送系统（IF=13.1）

Ye Chen, Xingyu Chen, Bowen Zhang, Yuxin Zhang, Songhang Li, Zhiqiang Liu, Yang Gao, Yuxuan Zhao, Lin Yan, Yi Li*, Taoran Tian*, Yunfeng Lin*. DNA Framework Signal Amplification Platform-based High-throughput Immune-cell Phenotyping System for Rapid Systemic Immune Monitoring. Signal Transduction and Targeted Therapy.   2024, 9(1):28. 基于DNA框架信号放大平台的高通量免疫细胞表型系统，用于快速系统免疫监测（IF=40.8）

Xingyu Chen, Ziang Xu, Yang Gao, Ye Chen, Wumeng Yin, Zhiqiang Liu, Weitong Cui, Yong Li, Jiafei Sun, Yuting Yang, Wenjuan Ma, Tao Zhang, Taoran Tian*, Yunfeng Lin*. Framework Nucleic Acid-based Selective Cell Catcher for Endogenous Stem Cell Recruitment. Advanced Materials. 2024, e2406118.基于框架核酸的选择性细胞捕获器用于内源性干细胞募集（IF=27.4）

Lan Yao, Geru Zhang, Yun Wang, Zhiqiang Liu, Jiale Liang, Jiafei Sun, Songhang Li, Taoran Tian*, Yunfeng Lin*. Development of an Inhalable DNA Tetrahedron MicroRNA Sponge. Advanced Materials. 2024, e2414336.可吸入的DNA四面体microRNA海绵的开发（IF=27.4）

Cui W, Guo Z, Chen X, Yan R, Ma W, Yang X*, Lin Y.* Targeting modulation of intestinal flora through oral route by an antimicrobial nucleic acid-loaded exosome-like nanovesicles to improve Parkinson's disease. Sci Bull (Beijing). 2024 Oct 24:S2095-9273(24)00771-0. 经口服途径通过载抗菌核酸的类外泌体纳米囊泡调节肠道菌群以改善帕金森病（IF=18.8）

Long Bai, Maogeng Feng, Qiuwen Zhang, Zhengwen Cai, Qiumei Li, Yong Li, Chuan Ma, Jingang Xiao*, Yunfeng Lin*.Synergistic Osteogenic and Anti-apoptotic Framework Nucleic Acid Complexes Prevent Diabetic Osteoporosis. Adv. Funct. Mater. 2024, 2314789协同成骨和抗凋亡框架核酸复合物预防糖尿病骨质疏松（IF=18.5）

Yuting Yang, Jinlong Yang, Jianwei Zhu, Xingyu Chen, Li Zhou, Wenjuan Ma*, Yunfeng Lina*. A DNA Tetrahedron-Based Nanosuit for Efficient Delivery of Amifostine and Multi-Organ Radioprotection. Bioactive Materials. 2024 May 21;39:191-205基于DNA四面体的纳米护甲：高效递送氨磷汀及多器官辐射保护. 生物活性材料（IF=18.0）

Liwei Fu, Jiang Wu, Pinxue Li, Yazhe Zheng, Zhichao Zhang, Xun Yuan, Zhengang Ding, Chao Ning, Xiang Sui, Shuyun Liu*, Sirong Shi*, Quanyi Guo*, Yunfeng Lin*. A novel mesenchymal stem cell-targeting dual-miRNA delivery system based on aptamer-functionalized tetrahedral framework nucleic acids: Application to endogenous regeneration of articular cartilage. Bioactive Materials. 2024;40: 634-648一种靶向间充质干细胞的适配体功能化四面体框架核酸双重miRNA递送系统：应用于关节软骨的内源性再生（IF=18.0）

Xie Y, Shi S, Lv W, Wang X, Yue L, Deng C, Wang D, Han J, Ye T*, Lin Y*. Tetrahedral Framework Nucleic Acids Delivery of Pirfenidone for Anti-Inflammatory and Antioxidative Effects to Treat Idiopathic Pulmonary Fibrosis. ACS Nano. 2024 Oct 1;18(39):26704-26721.四面体框架核酸递送吡非尼酮治疗特发性肺纤维化（IF=15.8）

Jin Y, Zhou X, Chen L, Xu X, Yan W, Wang Q, Lin Y*, Ding X*. Framework Nucleic Acids Loaded with Quercetin: Protecting Retinal Neurovascular Unit via the Protein Kinase B/Heme Oxygenase-1 Pathway. ACS Nano. 2024 Sep 13. doi: 10.1021/acsnano.4c05845. 负载槲皮素的框架核酸：通过蛋白激酶B/血红素氧化酶-1通路保护视网膜神经血管单元 （IF=15.8）

Zhengwen Cai, Long Bai, Qiumei Li, Yong Li, Xiaoxiao Cai, and Yunfeng Lin *. Gene-activating Framework Nucleic Acid Targeted Upregulating Sirtuin-1 to Modulate Osteoimmune Microenvironment for Diabetic Osteoporosis Therapeutics. ACS Nano. 2024 Dec 17. doi: 10.1021/acsnano.4c08727.基因激活框架核酸靶向上调Sirtuin-1以调控骨免疫微环境治疗糖尿病骨质疏松症. （IF=15.8）

Yueying Jiang, Songhang Li, Ruijianghan Shi, Wumeng Yin, Weitong Lv, Taoran Tian,*, Yunfeng Lin*. A Novel Bioswitchable MiRNA Mimic Delivery System: Therapeutic Strategies Upgraded from Tetrahedral Framework Nucleic Acid System for Fibrotic Disease Treatment and Pyroptosis Pathway Inhibition. Advanced Science. 2024;11(1):e2305622. 一种新型可生物切换的miRNA递送系统用于纤维化疾病治疗和焦亡途径抑制. （IF=14.3）

Qiguang Wang, Jian Cheng, Fei Liu, Jianwei Zhu, Yue Li, Yuxuan Zhao, Xiang Li, Huan Zhang, Yan Ju, Lu Ma, Xuhui Hui*, Yunfeng Lin*. Modulation Of Cerebrospinal Fluid Dysregulation Via a SPAK and OSR1 Targeted Framework Nucleic Acid In Hydrocephalus. Advanced Science. 2024, 2306622 SPAK和OSR1靶向型框架核酸调节脑脊液失调以治疗脑积水. Advanced Science. 2024, 2306622. （IF=14.3）

Songhang Li, Yuxuan Zhao, Xiaoying Lyu, Ye Chen, Tao Zhang, Shiyu Lin, Zhiqiang Liu, Xiaoxiao Cai, Taoran Tian, * and Yunfeng Lin*. Enzyme-Responsive Nanoparachute for Targeted miRNA Delivery: A Protective Strategy Against Acute Liver and Kidney Injury. Advanced Science. 2024 Dec 24:e2411210.酶响应型纳米降落伞通过靶向递送miRNA对急性肝肾损伤进行保护（IF=14.3）

Yong Li, Zhengwen Cai, Wenjuan Ma, Long Bai, En Luo*, Yunfeng Lin*. A DNA Tetrahedron-based Ferroptosis-suppressing Nanoparticle: Superior Delivery of Curcumin and Alleviation of Diabetic Osteoporosis. Bone Research. 2024, 12:14. 通过负载姜黄素的DNA四面体抗铁死亡纳米颗粒缓解糖尿病骨质疏松症. （IF=14.3）

Yikai Dou, Xiao Yang, Yue Du, Weitong Cui, Yuling Luo, Jinxue Wei, Liansheng Zhao, Xiaoxiao Cai, Xiaohong Ma*and Yunfeng Lin*. Early-relief Effects of Tetrahedral DNA Nanostructures-Assisted Depression Therapy via Modulates Hippocampal Neurogenesis and Neuroplasticity. Chemical Engineering Journal. 2024, 491, 152031四面体DNA纳米结构通过调节海马神经发生和神经可塑性辅助抑郁症治疗的早期缓解作用（IF=13.3）

Yuhao Liu, Chongmai Zeng, Zhangheng Huang, Weijie Zhuang, Xiangyi Chen, Songhang Li, Zhiqiang Liu, Zhengwen Cai, Jianwei Zhu, Yunfeng Lin. A Celastrol-loaded DNA Nano-patroller Regulates Hypothalamus Leptin Sensitivity and Adipose Energy Expenditure for Anti-obesity Therapy. Chemical Engineering Journal. 2024, 486, 150419. 负载雷公藤红素的DNA纳米巡逻器通过调节下丘脑瘦素敏感性及脂肪能量消耗用于抗肥胖治疗. （IF=13.3）

Wei Wang, Ran Yan, Lede Lin, Liao Peng, Yang Xiong, Huiling Chen, Xiaoshuai Gao, Kun Liu, Liang Zhou*, Yunfeng Lin*. Amelioration of Radiation Cystitis by Tetrahedral Framework Nucleic Acid Nanostructures Functionalized with Quercetin. Chemical Engineering Journal. 2024, 493, 152736. 搭载槲皮素的四面体框架核酸纳米结构缓解放射性膀胱炎. （IF=13.3）

Shijian Feng, Ran Yan, Cai Tang, Zhaofa Yin, Bohan Liu, Pengan Chen, Yushi He, Liang Zhou*, Yunfeng Lin*. Modulating Ferroptosis for the Prevention of Urinary Stone Recurrence: An Innovative Strategy Employing Tetrahedral Framework Nucleic Acids and Polydatin Conjugates Chemical Engineering Journal. 2024, 496,153655. 四面体框架核酸-白藜芦醇复合物在调节铁死亡预防尿路结石复发中的应用. （IF=13.3）

Bicai Tang, Yuting Yang, Yong Li, Yutian He, Yichen Ge, Yangxue Yao, Wenjuan Ma*, Yunfeng Lin*. Suppression of Pathological Neovascularization by Anti-Flt1 Peptide Functionalized DNA Tetrahedron. Chemical Engineering Journal. 2024, 495, 153249搭载抗Flt1肽的功能化DNA四面体抑制病理性新生血管生成.（IF=13.3）

Liwei Fu, Jiang Wu, Sirong Shi, Zhichao Zhang, Yazhe Zheng, Pinxue Li, Xun Yuan, Zhengang Ding, Chao Ning, Xiang Sui, Shuyun Liu*, Quanyi Guo*, Yunfeng Lin*. A tetrahedral framework nucleic acids-based gene therapeutic nanococktail alleviates cartilage damage and protects against osteoarthritis progression. Chemical Engineering Journal. 2024, 498, 155189. 基于四面体框架核酸的基因治疗纳米复合物缓解软骨损伤并缓解骨关节炎进展. （IF=13.3）

Yanjing Li, Jiayin Li, Yuqi Chang, Junjiang Zhang, Zheng Wang, Feng Wang, Yunfeng Lin*, Lei Sui*. Mitochondria-targeted drug delivery system based on tetrahedral framework nucleic acids for bone regeneration under oxidative stress. Chemical Engineering Journal. 2023, 496, 153723基于四面体框架核酸的线粒体靶向药物递送系统在氧化应激条件下促进骨再生. （IF=13.3）

Jiale Liang, Xin Qin, Siqi Xu, Mei Zhang, Lan Yao, Zhiqiang Liu, Geru Zhang, Taoran Tian*, and Yunfeng Lin*. The construction of a peptide vaccine with multifunctional DNA tetrahedron exoskeleton. Chemical Engineering Journal. 2024, 502, 157911以多功能四面体外壳为基础构建的多肽疫苗.（IF=13.3）

Ye Chen, Zhiqiang Liu, Bowen Zhang, Haoyan Wu, Xiaoying Lv, Yuxin Zhang*, Yunfeng Lin*. Biomedical Utility of Non-enzymatic DNA Amplification Reaction: From Material Design to Diagnosis and Treatment. Small, 2024 Aug 17:e2404641  非酶促DNA扩增反应的生物医学应用：从材料设计到诊断与治疗.（IF=13）

Xiaoying Lyu, Haoyan Wu, Ye Chen, Yue Sun, Xiaoxiao Cai, Songhang Li*and Yunfeng Lin*. A Multifunctional Nanocomplex as miRNA/ Antibiotic Co-delivery System Based on Tetrahedral Framework DNA: Application to Infected Wound Healing. Small. 2024 Sep 16:e2406629. 四面体框架核酸多功能纳米复合物作为miRNA/抗生素共递送系统用于促进感染伤口的愈合. （IF=13）

Liang J, Yao L, Liu Z, Chen Y, Lin Y*, Tian T*. Nanoparticles in Subunit Vaccines: Immunological Foundations, Categories, and Applications. Small. 2024 Nov 6:e2407649. 纳米颗粒在亚单位疫苗中的作用：其免疫学基础、分类和具体应用（IF=13）

Zhengyang Yang, Lin Shi, Yun Wang, Dongfang Zhou, Chao Zhang*, Yunfeng Lin*. Unveiling the Potential of Tetrahedral DNA Frameworks in Clinical Medicine: Mechanisms, Advances, and Future Perspectives. Small. 2024 Dec 20:e2410162. 四面体DNA框架在临床医学中的潜力：机制、进展与未来展望. （IF=13）

Li C, Feng X, Li S, He X, Luo Z, Cheng X, Yao J, Xiao J, Wang X, Wen D, Liu D, Li Y, Zhou H, Ma L, Lin T, Cai X, Lin Y*, Guo L*, Yang M*. Tetrahedral framework nucleic acids loaded siCCR2 restrains M1 macrophage polarization to ameliorate pulmonary fibrosis in chemoradiation-induced murine model. Mol Ther. 2024 Jan 24:S1525-0016(24)00022-4. 负载siCCR2的四面体框架核酸抑制M1巨噬细胞极化，以改善化学放疗诱导小鼠模型的肺纤维化. （IF=12.1）

Daxu Zhang, Liwei Fu, Yuting Yang, Quanyi Guo, Jingjing Hu, Pinxue Li, Shuo Zhao, Xiaonan Shi, WeiLong Li, Yunfeng Lin*, Wenping Lu*, Li Yan*. Tetrahedral framework nucleic acids improve the effectiveness of adipose-derived mesenchymal stem cells in the repair of acute liver failure. Materials Today Nano. 2024, Accepted. 四面体框架核酸通过提高脂肪来源间充质干细胞以修复急性肝衰竭. （IF=13.2）

Cai Qi, Qiang Sun, Dexuan Xiao, Mei Zhang, Shaojingya Gao, Bin Guo*, Yunfeng Lin*. Tetrahedral Framework Nucleic Acids/Hyaluronic Acid-methacrylic Anhydride Hybrid Hydrogel with Antimicrobial and Anti-inflammatory Properties for Infected Wound Healing. International Journal of Oral Science. 2024;16(1):30.具有抗菌和抗炎特性的四面体框架核酸/HAMA混合水凝胶用于感染性伤口愈合. （IF=10.8）

Jingwen Wang, Peizhang Zhao, Mengmeng Li, Jun Li*, Yunfeng Lin*. Remedying infectious bone defects via 3D printing technology. Chinese Chemical Letters. 2024,Accepted通过3D打印技术修复感染性骨缺损.（IF=9.4）

Lihang Wang, Mary Li Javier, Chunshan Luo, Tingsheng Lu, Shudan Yao, Bing Qiua, Yun Wang, Yunfeng Lin. Research advances of tetrahedral framework nucleic acid-based systems in biomedicine. Chinese Chemical Letters. 2024, doi: 10.1016/j.cclet.2024.109591 四面体框架核酸系统在生物医学领域的研究进展. （IF=9.4）

Jiangshan Xu, Weifei Zhan , Zhengwen Cai , Yong Li , Long Bai , Shaojingya Gao , Qiang Sun , Yunfeng Lin Tetrahedron DNA nanostructure/iron-based nanomaterials for combined tumor therapy. Chinese Chemical Letters. 2024, doi:10.1016/j.cclet.2024.109620 四面体框架核酸-铁基纳米粒子复合物在肿瘤治疗中的应用（IF=9.4）

Dexuan Xiao, Tianyu Chen, Tianxu Zhang, Sirong Shi, Mei Zhang, Xin Qin, Yunkun Liu, Longjiang Li, Yunfeng Lin, Transdermal treatment for malignant melanoma by aptamer-modified tetrahedral framework nucleic acid delivery of vemurafenib, Chinese Chemical Letters. 2024, 35, 108602 适配体修饰的四面体框架核酸经皮递送维莫非尼进行恶性黑色素瘤的治疗. Chinese Chemical Letters. 2024; 35: 108602. （IF=9.4）

Yanjing Li, Jiayin Li ,Yuqi Chang ,Yunfeng Lin*, Lei Sui*.Tetrahedral framework nucleic  acids promote the proliferation and differentiation potential of diabetic bone marrow mesenchymal stem cell. Chinese Chemical Letters. 2024, 35 (9), 109414. 四面体框架核酸促进糖尿病骨髓间充质干细胞的增殖和分化潜能.（IF=9.4）

Kai Wang, Yun Wang, Lihang Wang, Zhuhai Li, Xi Yu, Xuanhe You, Diwei Wu, Yueming Song, Jiancheng Zeng, Zongke Zhou, Shishu Huang*, Yunfeng Lin*. Therapeutic siRNA targeting C-C chemokine receptor 2 loaded with tetrahedral framework nucleic acid alleviates neuropathic pain by regulating microglial polarization. Chinese Chemical Letters. 2024, 109868.搭载siCCR2的四面体框架核酸通过调节小胶质细胞极化来治疗缓解神经性疼痛（IF=9.4）

Shengnan Liao, Zhiqiang Liu, Weitong Lv, Songhang Li, Taoran Tian, Yifan Wang, Haoyan Wu, Zhihe Zhao*, and Yunfeng Lin*. Efficient Delivery of siRNA via Tetrahedral Framework Nucleic Acids: Inflammation Attenuation and Matrix Regeneration in Temporomandibular Joint Osteoarthritis. ACS Appl Mater Interfaces. 2024 Oct 9;16(40):53499-53514.四面体框架核酸高效递送siRNA：用于颞下颌关节骨关节炎的炎症缓解与基质再生. （IF=8.3）

Weifei Zhang, Mengqing Li, Zhen Zhao, Jiangshan Xu, Junlin Liu, Pin Feng, Bin Zhang, Zhangheng Huang*, Qing-quan Kong*, Yunfeng Lin*. Tetrahedral Framework Nucleic Acid-loaded Retinoic Acid Promotes Osteosarcoma Cancer Stem Cell Clearance. ACS Appl Mater Interfaces. 2024 Oct 19. doi: 10.1021/acsami.4c14440.载有视黄酸的四面体框架核酸促进骨肉瘤癌症干细胞的清除. （IF=8.3）

Yutian He, Zhiqiang Liu, Songhang Li, Shengnan Liao, Bicai Tang, Yunfeng Lin*. A Tetrahedral Framework DNA-Based Bioswitchable miR-150 Delivery System for Sepsis. ACS Appl Mater Interfaces. 2024 Oct 18. doi: 10.1021/acsami.4c14928. 基于四面体框架DNA的可切换miR-150递送系统用于治疗败血症. （IF=8.3）

Weitong Cui, Xiao Yang, Yikai Dou, Yue Du, Xiaohong Ma, Lei Hu, Yunfeng Lin*. Effects of tetrahedral DNA nanostructures on the treatment of osteoporosis. Cell Prolif. 2024 Feb 27:e13625.四面体DNA纳米结构对骨质疏松治疗的作用. （IF=5.9）

Yuanchong Chen, Jiangshan Xu, Sirong Shi, Wenjuan Ma, Weitong Cui, Ran Yan, Yunfeng Lin*. A DNA Nanostructure-Hif-1α Inducer Complex as Novel Nanotherapy Against Cisplatin-Induced Acute Kidney Injury. Cell Prolif. 2024 Jan 14:e13601.一种DNA纳米结构-Hif-1α诱导剂复合物治疗顺铂诱导的急性肾损伤. （IF=5.9）

Siqi Xu, Xin Qin, Jiale Liang, Xiao Fu, Dexuan Xiao, Yunfeng Lin*, Tao Wang*. Harnessing Tetrahedral Framework Nucleic Acids for Enhanced Delivery of microRNA-149-3p: A New Frontier in Oral Squamous Cell Carcinoma Therapy. Cell Prolif. 2024 Apr 26:e13637.四面体框架核酸搭载microRNA-149-3p治疗口腔鳞状细胞癌. Cell Proliferation. e13637. （IF=5.9）

Shengnan Liao, Songhang Li, Zhiqiang Liu, Weitong Lu, Yutian He, Kai Xia, Yigan Wang, Zhihe Zhao, * Yunfeng Lin*. A Bioswitchable siRNA Delivery System: RNAi Therapy Based on Tetrahedral Framework Nucleic Acids for Bone Defect Repair. Nanoscale, 2024, 16, 21531 - 21544.一种可切换四面体框架核酸的siRNA递送系统用于骨缺损修复. （IF=5.8）