Expert Team

Yunfeng Lin

Chief Scientist at Yunhai Biotech

Outstanding achievements in the research of framework nucleic acid nanomaterials for gene and drug delivery

First inventor on over 100 national and international patents related to tetrahedral framework nucleic acids

Recipient of the IADR Distinguished Scientist Award

Deputy Secretary of the Party Committee, West China School of Stomatology, Sichuan University
Deputy Director of the State Key Laboratory of Oral Diseases
Changjiang Scholar Distinguished Professor
Top 2% of scientists globally

Yunfeng Lin is a Second-Level Professor, Chief Physician, and Doctoral Supervisor. He serves as the Deputy Director of the State Key Laboratory of Oral Diseases, Deputy Party Secretary of the West China School of Stomatology at Sichuan University, and Chief Specialist in Maxillofacial Surgery at West China Hospital of Stomatology. Lin has been recognized as a Changjiang Scholar Distinguished Professor, selected for the Ten Thousand Talents Program by the Organization Department of the Central Committee, and awarded the National Health and Medical Outstanding Contribution Expert for Young and Middle-aged Professionals. He has also been named a Leading Talent in Scientific and Technological Innovation by the Ministry of Science and Technology, received the National Award for Outstanding Doctoral Dissertations, and was included in the New Century Excellent Talents Program by the Ministry of Education, as well as other prestigious programs such as the Tianfu Ten-Thousand Talents Program, Sichuan Academic and Technological Leaders, and Sichuan Provincial Health Leaders.

Lin has earned over ten significant awards, including the International Association for Dental Research (IADR) Distinguished Scientist Award, the China Youth Science and Technology Award, the Second Prize in Natural Science from the Ministry of Education, the Second Prize in Scientific and Technological Progress from the Ministry of Education, the National Award for Outstanding Doctoral Dissertations, the Chinese Medical Association Youth Science and Technology Award, the Second Prize in Stomatological Science and Technology from the Chinese Stomatological Association, and the Sichuan Province Innovation and Excellence Medal.

His research focuses on nucleic acid nanomaterials and oral tissue regeneration. Lin has published 255 SCI papers as corresponding/first author, with the highest impact factor reaching 40.8.  And he authored 81 papers with impact factors above 10. His works include 3 F1000-recommended papers, 26 cover articles, 8 ESI Hot Papers, and 32 ESI Highly Cited Papers, with over 16,000 citations. He has consistently been recognized as one of Elsevier's Most Cited Chinese Researchers and is ranked among the top 2% of scientists globally. Lin has also edited eight English monographs.

In terms of technological innovations, Lin has applied for 112 Chinese invention patents, been granted two U.S. patents, and applied for five international PCT patents. He holds 50 granted Chinese invention patents, with nine transferred patents and 71 patents under active implementation. He has twice won Excellence Awards in the Ministry of Science and Technology's National Disruptive Technology Innovation Competition and an Excellence Award in the cutting-edge biopharmaceutical field at the 2023 Golden Panda Global Innovation and Entrepreneurship Competition. Four of his innovative Class 1.1 drugs are in the preclinical stage, and one is expected to enter clinical trials in 2024. He successfully completed the first U.S. Drug Master File (DMF) registration for a framework nucleic acid drug (FDA: MFO39406) and the first pre-IND application for a framework nucleic acid drug (China's National Medical Products Administration: 2024000818).

Lin also serves in multiple academic roles. He is the Executive Editor of Bone Research and Cell Proliferation, an Editorial Board Member of the Journal of Dental Research, and a Fellow of the International College of Dentists. He holds leadership positions in various academic and professional organizations, including serving as Vice Chairman of the Scientific Research Management Committee of the Chinese Stomatological Association, Vice President of the Tissue Regeneration Branch of the China Association of Medical Equipment, Standing Committee Member of the Oral Biology Branch of the Chinese Stomatological Association, Vice President of the Sichuan Youth Science and Technology Federation, Vice President and Secretary-General of the Sichuan Stomatological Association, and Chairman of the Oral Materials Committee of the Sichuan Stomatological Association.


Chunhai Fan

Pioneer in Framework Nucleic Acid Technology

Chief Scientist at the National Center for Translational Medicine, Tang Zhongying

Proposer of the Framework Nucleic Acids (FNAs) Concept

One of the earliest scientists involved in DNA origami research in China

Academician of the Chinese Academy of Sciences
Dean of the School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University
Executive Director of the Translational Medicine Research Institute
Director of the Shanghai Key Laboratory of Nucleic Acid Chemistry and Nanomedicine

Chunhai Fan, male, is the Chief Scientist of the Tang Zhongying National Center for Translational Medicine, a Wang Kuancheng Chair Professor at Shanghai Jiao Tong University, primarily focusing on the ordered interface construction and biological applications of DNA nanotechnology. He is an academician of the Chinese Academy of Sciences, a central committee member of the Jiusan Society, the Dean of the School of Chemistry and Chemical Engineering at Shanghai Jiao Tong University, Executive Director of the Translational Medicine Research Institute, and Chief Scientist of the National Key Research and Development Program (Nanotechnology) of the Ministry of Science and Technology. He is also a fellow of the American Association for the Advancement of Science (AAAS), the International Society of Electrochemistry (ISE), the American Institute for Medical and Biological Engineering (AIMBE), the Chinese Chemical Society (CCS), and the Royal Society of Chemistry (RSC). He has received the Ho Leung Ho Lee Foundation Science and Technology Innovation Award and serves as Associate Editor of JACS-Au under the American Chemical Society, as well as an editorial board member for Angewandte Chemie, Accounts of Chemical Research, ACS Nano, and over ten other internationally renowned journals. He is also the Co-Chair of the Editorial Board of ChemPlusChem.

Leading his team, Professor Fan developed a novel method for DNA self-assembly-induced precise nanoscale mineralization, which was published in Nature, marking the first major breakthrough by Chinese researchers in the field of DNA nanotechnology. Since 2014, he has consistently been named a "Highly Cited Researcher" globally, and at the age of 45, he became an academician of the Chinese Academy of Sciences, currently the youngest academician in Shanghai. His research areas include DNA self-assembly, DNA storage, molecular machines, and their clinical translation, aiming to contribute to human health. He has published over 700 academic papers internationally, with approximately 80,000 citations,and an H-index of 130.

Professor Fan's achievements are not only reflected in academic research but also in his dedication to translating scientific discoveries into real-world applications, contributing to society and human health. He has guided and fully participated in the overall design and strategic direction of the tetrahedral framework nucleic acid drug system. Additionally, he serves as the Chair of the Global Tetrahedral Framework Nucleic Acid Industry Development Forum.


Delun Luo

President of Yunhai Biotech

Spearheaded the launch of the world’s first monoclonal antibody-based targeted therapy for liver cancer, Likatin

Led the development of China’s first internationally recognized ophthalmic drug, Langmu

Oversaw the completion of the global first tetrahedral framework nucleic acid drug’s API registration in the US and Pre-IND application in China


Leader in the Tianfu Qingcheng Plan for Technological Innovation
Deputy Director of the Sichuan University-Yunhai Biotech Joint Research Laboratory on Tetrahedral Framework Nucleic Acids
Professor at Chengdu University of Traditional Chinese Medicine
Vice President of the Wisdom Immunology Branch of the Sichuan Bioinformatics Society

Professor Delun Luo has served as an advisor at the Ophthalmology Research Institute of Shanghai Jiao Tong University, Vice President of Jingze Biomedicine (Hefei) Co., Ltd., Managing Director of Chengdu Jingrunze Gene Technology Co., Ltd., Managing Director of Chengdu Nuon Gene Technology Co., Ltd., Deputy Director of the Enterprise Technology Center and Medical Department Director at Chengdu Kanghong Pharmaceutical Group, Deputy General Manager at Kanghong Biotech, and Senior Project Manager at Chengdu Huashen Group. He has been involved in and led the research and development of over 20 national class 1 new drugs. These include:

  • Likatin (Iodine [131I] Metuximab Injection), the world’s first monoclonal antibody-based targeted therapy for liver cancer, which has been launched.
  • Langmu (Conbercept Injection), which has accumulated sales exceeding 10 billion RMB.
  • 1 biologic drug application for NDA.
  • 3 drugs in Phase III clinical trials.
  • 3 drugs in Phase I clinical trials.
  • 6 drugs in preclinical research.

He successfully completed the global first tetrahedral framework nucleic acid drug’s API registration in the US (FDA: MFO39406) and Pre-IND application in China (Application No: 2024000818).

Professor Luo has been comprehensively involved in and responsible for multiple new drugs throughout the entire process, from molecular construction and preclinical and clinical development to regulatory approval and product launch, possessing extensive clinical and project development experience. He has applied for 27 patents, with 9 granted and 8 PCT applications. He has led and participated in over 20 national and provincial-level projects, including the National 973 Program, the "11th Five-Year Plan," and the "12th Five-Year Plan" major national new drug creation projects, with total project funding exceeding 30 million RMB.

Rong Li

Vice President at Yunhai Biotech

Involved in the development of 4 innovative new drugs, leading technology innovation and operational management

Led the registration application for the original class 1 new drug, Conbercept

Successfully facilitated the first listing of a Southwest China-based company on the Science and Technology Innovation Board in Chengdu


Technology innovation expert, project evaluation expert, and registration strategy expert in Chengdu, Sichuan Province
Professor at Chengdu University of Traditional Chinese Medicine

Professor Rong Li has over 30 years of experience in new drug registration, application, and development management. She has been involved in the research and development of nine biologic innovative new drugs, including Conbercept Injection, Iodine [131I] Metuximab Injection, and Vascular Epidermal Growth Factor Eye Drops. She has held positions such as Vice President at Sichuan Huashen Group, Executive Deputy Director of the Enterprise Technology Center at Chengdu Kanghong Pharmaceutical Group, and Vice President of Operations at Chengdu XianDao.

With extensive experience in new drug development, IND/NDA registration applications, and R&D management, Professor Li has a deep understanding of national medical policies and drug regulations, particularly in new drug registration strategies and related laws. She possesses strong scientific insight, registration strategy expertise, and application capabilities, and has trained a number of key personnel in registration and government affairs for pharmaceutical companies in Sichuan.

Among the nine innovative drugs Professor Li has been responsible for or involved in, 4 have received new drug certificates, and 2 class 1 biologic innovative drugs are already on the market. She has long served as a project evaluation expert for innovation work in Sichuan Province and Chengdu City, organizing and participating in numerous national and provincial-level projects, including several major national new drug creation projects, national innovation capability construction projects, national high-tech industrialization projects, Sichuan Province strategic emerging industry projects, and science and technology support projects.