Innate and adaptive immunity are two crucial components of the immune system. Innate immunity is responsible for recognizing imbalances in the body caused by infectious or non-infectious assaults, while adaptive immunity, which includes cell-mediated and humoral immunity...

Learn More

This invention provides a tetrahedral framework nucleic acid-quercetin complex, along with its prepa...

Learn More

tFNAs treatment can be used to treat severe acute pancreatitis in mice and associated multi-organ da...

Learn More

The team successfully developed tFNA, a nanoparticle with excellent biomedical value. tFNA can work...

Learn More

tFNA has excellent biocompatibility, along with anti-inflammatory and antioxidant functions, effecti...

Learn More

A novel and effective tFNA delivery system has been developed for the delivery of AOS. By inhibiting...

Learn More

The complex described in this invention effectively inhibits the activation of hepatic stellate cell...

Learn More

The challenges associated with muscle degenerative diseases and volumetric muscle loss (VML) highlight the prospects of muscle tissue regeneration. In particular, maintaining the stemness and self-renewal of myoblasts to rapidly produce a sufficient number of cells underscores the importance of both...

Learn More

The present invention provides a new use for Typhaneoside in treating acute kidney injury and disclo...

Learn More

Revealing M1 macrophages as potential therapeutic targets, and establishing new therapeutic strategies using FNA-siCCR2, which is highly relevant to clinical scenarios and translational research in the field of IPF....

Learn More

The technical team successfully synthesized a complex designed for bone marrow injury and/or suppression. This complex is composed of a tetrahedral DNA framework combined with an osteogenic polypeptide, providing bone marrow protection....

Learn More

tFNAs primarily exert a protective effect on cells by alleviating oxidative stress and inhibiting apoptosis. These characteristics of tFNAs significantly enhance renal enrichment and reduce kidney injury following injection in an Acute Kidney Injury (AKI) model. Our research findings indicate that t...

Learn More

This invention discloses a drug for treating depression, belonging to the field of nervous system medications. The drug described in this invention can reduce cytotoxicity in vitro and alleviate corticosterone (CORT)-induced proliferation inhibition. In vivo, it reduces synaptic loss, improves neuro...

Learn More

These results suggest that tFNA is a safe and multi-functional neuroprotective nanoagent and a promising therapeutic strategy for ischemic stroke....

Learn More

Overall, our results once again demonstrate the immunomodulatory capacity of tFNAs, which may provide a new, safe, and effective option for the treatment of SS and other autoimmune diseases....

Learn More

The tFNA developed in this invention can effectively prevent oxidative stress and apoptosis induced by tert-butyl hydroperoxide, thereby providing significant protection to RGC-5 cells. Using tFNA in the preparation of drugs to prevent oxidative stress in retinal ganglion cells could be beneficial f...

Learn More

Optic nerve protection is one of the critical challenges in the treatment of glaucoma in the 21st century, with an urgent need for therapeutic measures to reduce or reverse these progressive optic nerve degenerative changes. MicroRNAs (miRNAs) have become important regulators of gene expression. Stu...

Learn More

In this study,tFNAs nanomaterial with high efficiency in loading resveratrol (RSV) was synthesized, aimed at inhibiting tissue inflammation and improving insulin resistance in obese mice. The nanoparticles prepared (tFNAs-RSV) are characterized by their simple synthesis, stable performance, good wat...

Learn More

The technical team has successfully developed a framework nucleic acid nanomaterial that improves insulin resistance. This material can efficiently enter liver cells without the need for transfection agents. By activating the PI3K/Akt signaling pathway and the insulin receptor pathway, it promotes g...

Learn More

Our results suggest that tFNAs treatment aids in glycemic control, provides β-cell protection, and prevents the onset of T1D in NOD mice via immune modulation. These results highlight the potential of tFNAs in preventing autoimmune T1D....

Learn More

The technical team successfully synthesized tFNAs, which can autonomously and efficiently enter neur...

Learn More

DNA nanotechnology offers new strategies and platforms for cargo delivery. Our research team has successfully developed a multifunctional nanobee system based on tetrahedral framework nucleic acid (tFNAs). This system demonstrates excellent stability, biocompatibility, cellular internalization abili...

Learn More

The technical team successfully synthesized the P-TDNs complex and demonstrated that P-TDNs can carry PNAs and be effectively taken up by multidrug-resistant bacteria. It was confirmed that P-TDNs can specifically target and inhibit the expression of the bacterial division key protein FtsZ, thereby...

Learn More

The invention provides a composite adjuvant comprising CpG-tFNA and mDF2β, as well as an mRNA nanoparticle vaccine based on this composite adjuvant. mRNA, without an adjuvant, is almost incapable of entering cells to exert its function. However, the mRNA nanoparticle vaccine using the composite adju...

Learn More

This nanobox offers a dynamic, pH-sensitive confined delivery system for siRNA and can be extended as a strategy for other small RNAs....

Learn More

MicroRNAs (miRs) play an important role in regulating gene expression. Limited by their instability...

Learn More

The team has successfully developed a PEI/TDNs complex for multifunctional delivery. This complex demonstrates excellent stability, biocompatibility, cellular internalization, and lysosomal escape capabilities in biological environments, making it a promising system for effective gene and drug deliv...

Learn More